The game takes place during World War II and its single-player campaign features battles set in Europe, the Soviet Union, Greece, and North Africa across three different campaigns for the Allies, Germans and Soviets. Japan was introduced as a multiplayer faction in a patch.
- United States of America
- Private Palmer, Terry (First appearance)
- Corporal Robinson (First appearance)
- Soviet Union
- Junior Lieutnant Smirnov, Victor (First appearance)
- Junior Lieutnant Kuznetsov, Alexei (First appearance)
- Main article: Men of War: Red Tide
- Main article: Men of War: Assault Squad
- Main article: Men of War: Vietnam
- Main article: Men of War: Condemned Heroes cuatro expanciones independientes han sido liberadas para el juego.
- Main article: Men of War 2
A true sequel has been rumored to be in-development.